SYNTHESIS AND CHARACTERIZATION OF PERIODIC POLYPEPTIDES CONTAINING REPEATING -(AlaGly),GluGly- SEQUENCES

نویسندگان

  • MARK T. KREJCHI
  • JANOS BORBELY
  • DAVID A. TIRRELL
چکیده

We have expressed in E. coli a series of periodic polypeptides represented by sequence 1. Our objective has been an understanding of the role of chemical sequence in determining the chain folding behavior of periodic macromolecules. Molecular organization has been examined by infrared spectroscopy and IH and l 3 ~ NMR methods and a preliminary model of the folded structure has been developed.

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تاریخ انتشار 2007